NanoBiotech Supporting Science & Clinical Trials

Studies specific to NanobacTX  (Click the blue links to read studies)

Altundag K, Altundag O, Akyurek S, Atik MA. Possible association between nanobacteria and malignant microcalcifications in breast cancer. Breast J.2006 May-Jun; 12(3):287www.ncbi.nlm.nih.gov

Puskas, L. G., L. Tiszlavicz, Zs Razga, L. Torday, T. Krenacs, J. G Papp. Detection of nanobacteria-like particles in human atherosclerotic plaques. Acta Biologica Hungarica 56 (3-4): 233-245www.ncbi.nlm.nih.gov 

Hudelist G., C. F. Singer, E. Kubista, M. Manavi, R. Mueller, K. Pischinger, K. Czerwenka. Presence of nanobacteria in psammoma bodies of ovarian cancer: evidence of pathogenetic role in intratumoral biomineralization. Histopathology. 45, 633-637Click here to view study.

Jelic T. M., A. M. Malas, S. S. Groves, B. Jin, P. F. Mellen, G. Osborne, R. Roque, J. G. Rosencrance, and H. H. Chang. Nanobacteria-caused mitral valve calciphylaxis in a man with diabetic renal failure. South Med J.Feb; 97 (2): 194- 198Click here to view study.

Lieske J. C., V. Kumar, G. Farell-Baril, S. Yu, J. E. Charlesworth, E. Rzewusk-Lech, P. LaBreche, S. R. Severson, and V. M. Miller. Mayo Clinic. Detection and propagation of calcified nanostructures from human aneurysm. J Am Coll Cardiol Abstracts Book. 1059-13: 13A. Click here to view study.

Maniscalco, B.S., Mezo, G.S. Calcification in coronary artery disease can be reversed. Intl Journal of Pathophysiology. 11(2): 95-101Click here to view study.

Miller, V. M., G. Rodgers, J. A. Charlesworth, B. Kirkland, S. R. Severson, T. E. Rasmussen, M. Yagubyan, J. C. Rodgers, F. R Cockerill, III, R. L. Folk, V. Kumar, G. Farell-Baril, J. C. Lieske. Mayo Clinic. Evidence of nanobacterial-like structures in human calcified arteries and cardiac valves. Am J Physiol Heart Circ Physiol. 287 (3): H1115-24. www.ncbi.nlm.nih.gov

Ciftcioglu, N., D. S. McKay, E.O. Kajander. Association between nanobacteria and periodontal disease. Circulation. 108:e58-9Click here to view study.

Kajander, E O. Nanobacteria do exist and actively participate in the calcification of arterial plaque. Townsend Letter 234:80-82. Click here to view study.

Sedivy, R., and W. B. Battistutti. Nanobacteria promote crystallization of psammoma bodies in ovarian cancer. APMIS III. 951-4. Click here to view study.

Sommer, A. P., U. Oron, A. M. Pretorius, D. S. McKay, N. Ciftcioglu, A. R. Mester, E. O. Kajander and H. T. Whelan, NASA-JSC. Light-modulated replication of nanobacteria and heart disease. J. Clin. Laser Med. Surg. 21 (4): 231-235. Click here to view study.

Ciftcioglu, N., M. A. Miller-Hjelle. J. T. Hjelle and E. O. Kajander. Inhibition of Nanobacteria as measured by a modified microdilution method. Antimicrob Agents Chemother. 46: 2077-2086. Click here to view study.

Kajander, E. O., K. Aho and V. Segal. Apatite biofilm forming agent: nanobacteria as a model system for biomineralization and biological standard for noa, a preliminary study. Proceedings of the 2nd International Conference on Near-Field Optical analysis. Houston, TexasClick here to view study.

Rasmussen, T. E., B. L. Kirkland, J. Charlesworth, et al. Electron microscope and immunological evidence of nanobacteria in calcified carotid arteries, aortic aneurysms and cardiac valves. J Am Coll Cardiol Abstracts Book. 1009-79: 206A. Click here to view study.

Lopez-Brea M., R. Selgas. Nanobacteria as a cause of renal diseases and vascular calcifying pathology in renal patients (endovascular lithiasis). Enferm Infec. Microbiol. Cli. (Spanish). 18(10):491-492. www.ncbi.nlm.nih.gov

Ciftcioglu, N., V. Ciftcioglu, H. Vali, E. Turcott, E. O. Kajander. Sedimentary rocks in our mouth: dental pulp stones made by nanobacteria. Proc. SPIE. 3441: 130-135. Click here to view study.

 

Studies specific to UROBAC

Wang L, Shen W, Wen J, An X, Cao L, Wang B. An Animal Model of Black Pigment Gallstones Caused by Nanobacteria. Digestive Diseases and Sciences, Vol. 51, No. 6 (June 2006), pp. 1126–1132 DOI: 10.1007/s10620-006-8019-6. www.ncbi.nlm.nih.gov

Shiekh FA, Khullar M, Singh SK. 2006. Lithogenesis: induction of renal calcifications by nanobacteria. Urological Research. 34(1):53-7. Click here to view study.

Jones, J.A., R. Jennings, D. Hamilton, A. Sargsyan, R. Pietryzk, N. Çiftçioglu, P. Stepaniak., NASA-JSC. Genitourinary Issues during Spaceflight: A Review. Int J Impot Res. 2005 Dec;17 Suppl 1:S64-7.  www.ncbi.nlm.nih.gov

Ciftcioglu, N., R. S. Haddad, D. C. Golden, D. R. Morrison, D. S. McKay. NASA-JSC. A cause of kidney stone formation during space flights: Enhanced growth of nanobacteria in microgravity. Kidney International. 67: 483-491. Click here to view study.

Rieu, P. Infective lithiasis. Ann Urol (Paris). 39(1):16-29.www.ncbi.nlm.nih.gov

Shoskes, D., K. Thomas, E. Gomez. CLEVELAND CLINIC. Antinanobacterial therapy in men with chronic prostatitis/chronic pelvic pain syndrome and prostatic stones. Journal of Urology. 173: 474-477. Click here to view study.

Wen, Y., Y. G. Li, Z. L. Yang, X. J. Wang, H. Wei, W. Liu, X. Y. Miao, Q. W. Wang, S. F. Huang, J. Yang, E. O. Kajander, N. Ciftcioglu. Detection of nanobacteria in serum , bile, and gallbladder mucosa of patients with cholecystolithiasis. Chin Med J (Engl). 118(5):421-424.www.ncbi.nlm.nih.gov

Goldfarb, D. S. Microorganisms and calcium oxalate stone disease. Nephron Physioil. 98(2):48-54www.ncbi.nlm.nih.gov

Khullar M., S. K. Sharma, S. K. Singh, P. Bajwa, F. A. Sheikh, V. Relan, and M. Sharma. Morphological and immunological characteristics of nanobacteria from human renal stones of a north indian population. Urological Research. 32 (3):190-195. Click here to view study.

Drancourt M., V. Jacomo, H. Lepidi, E. Lechevallier, V. Grisoni, C. Coulange, E. Ragni, C. Alasia, B. Dussol, Y. Berland, D. Raoult. Isolation of Nanobacterium sp. Microorganisms from upper urinary tract stones. J Clin Microbiol. 41(1):368-372. www.ncbi.nlm.nih.gov

Garcia Cuerpo, E. Nanobacteria and urinary stystem lithiasis. Arch. Esp. Urol.(Review Spanish). 56(2):191-192. www.ncbi.nlm.nih.gov

Kajander, E. O., N. Ciftcioglu, K. Aho and E. Garcia-Cuerpo. Characteristics of nanobacteria and their role in stone formation Urol Res. 31 (2): 47-54Click here to view study.

Rahman, N. U., M. V. Meng, M. L. Stoller 2003. Infections and urinary stone disease. Curr Pharm Des. 9(12):975-981. www.ncbi.nlm.nih.gov

Wen, Y., Y. G. Li, Z. L. Yang, X. J. Wang, H. Wei, W. Liu, A. L. Tan, X. Y. Miao, Q. W. Wang, S. F. Huang, E. O. Kajander, N. Ciftcioglu. Nanobacteria in serum, bile and gallbladder mucosa of cholecystolithiasis patients. Zhonghua Wai Ke Za Zhi. Apr; 41 (4): 267-270Click here to view study.

Li, Y., Wen, Y. Yang, Z., Wei, H., Liu, W., Tan, A., Wu, X., Wang, Q., Huang, S., Kajander, E. O., Ciftcioglu, N.. Culture and identification of nanobateria in bile. Zhonghua Yi Xue Za Zhi. 82 (22):1557-60. Click here to view study. 

Sommer, A. P., and E. O. Kajander. Nanobacteria-induced kidney stone formation: novel paradigm based on the fermic model. Crystal Growth & Design. 2:563-565. Click here to view study.

Conte Visus A., F. Grases Freixedas, A. Costa-Bauza, P. Piz Reus. Microinfections and kidney lithiasis. Arch Esp Uro. (Spanish). 54(9) :855-860. www.ncbi.nlm.nih.gov

Kajander, E. O., N. Ciftcioglu, M. A. Miller-Hjelle and J. T. Hjelle. Nanobacteria: controversial pathogens in nephrolithiasis and polycystic kidney disease. Current Opinions in Nephrology and Hypertension. 10:445-452. Click here to view study.

Garcia Cuerpo, E., O. Kajander, N. Ciftcioglu, F. Lovaco Castellano, C. Correa, J. Gonzalez, F. Mampaso, F. Liano, E. Garcia de Gabiola, A. Escudero Barrilero. Nanobacteria. An experimental neo-lithogenesis model. Arch Esp Urol. 53(4):291-303. Click here to view study.

Hjelle, J. T., M. A. Miller-Hjelle, I. R. Poxton, O. Kajander, N. Ciftcioglu, M. L. Jones, R. C. Caughey, R. Brown, P. D. Millikin, F. S. Darras. Endotoxin and nanobacteria in polycystic kidney disease. Kidney International. 57: 2360-2374. Click here to view study.

Kramer, G., H. C. Klingler, G. E. Steiner. Role of bacteria in the development of kidney stones. Curr Opin Urol. 10(1):35-38. www.ncbi.nlm.nih.gov

Lopez-Brea M., R. Selgas. Nanobacteria as a cause of renal diseases and vascular calcifying pathology in renal patients (endovascular lithiasis). Enferm Infec. Microbiol. Cli. (Spanish). 18(10):491-492. www.ncbi.nlm.nih.gov

Ciftcioglu, N., M. Bjorklund, K. Kuorikoski, K. Bergstrom and EO. Kajander. Nanobacteria: An infectious cause for kidney stone formation. Kidney International. 56:1893-1898. Click here to view study.

Dorrell, S. Nanobacteria linked to kidney disease. Mol. Med. Today.5(9):373www.ncbi.nlm.nih.gov

Studies specific to DERMATOLOGY:

Harvima, Rauno MDAssociation of Nanobacteria with Dermatologic Diseases. International Nanobacteria Symposium. Kuopio, Finland; 3/8/2001Click link to view study.

Morgan, M. B. Nanobacteria and calcinosis cutis. J. Cutan Pathol.29(3):173-175www.ncbi.nlm.nih.gov

Studies specific to Pathological Calcification & CNPs (aka Nanobacteria):

Kajander EO. Nanobacteria - propagating calcifying nanoparticles. Lett Appl Microbiol. 2006 Jun; 42(6):549-52. Click here to view study.

Altundag K, Altundag O, Akyurek S, Atik MA. Association between nanobacteria and malignant microcalcifications in breast cancer. Breast J.2006 May-Jun; 12(3):287. www.ncbi.nlm.nih.gov

Tsurumoto T., T. Matsumoto, A. Yonekura, and H. Shindo. 2006. Nanobacteria in Human Arthritic Synovial Fluids. Journal of Proteome Research. ASAP Article 10.1021/pr050450w S1535-3893(05)00450-1 [Web Release April 8, 2006] American Chemical Societypubs.acs.org Click here to view study.

Ciftçioglu, N. Nanobacteria-Discovery of a new form of life. Horizons 2006 March 31: 7-8. www.aiaa-houston.org/newsletter

Sommer, A. P., N. C. Wichramasinghe. 2005. Functions and Possible Provenance of Primordial Proteins-Part II: Microorganism Aggregation in Clouds Triggered by Climate Change. Journal of Proteome Research. 4: 180-184. Click here to view study.

Sommer, A. P. 2005. Primordial proteins and HIV-Part II. Journal of Proteome Research. 4(3): 1022 - 1024. www.ncbi.nlm.nih.gov

Sommer, A. P., A. E. Pavlath. 2005. Primordial proteins and HIV. Journal of Proteome Research. 4(2): 633-636. www.ncbi.nlm.nih.gov

Hudelist G., C. F. Singer, E. Kubista, M. Manavi, R. Mueller, K. Pischinger, K. Czerwenka. 2004. Presence of nanobacteria in psammoma bodies of ovarian cancer: evidence of pathogenetic role in intratumoral biomineralization. Histopathology. 45, 633-637. Click here to view study.

Pretorius, A. M., A. P. Sommer, K. M. Aho, E. O. Kajander. 2004. HIV and nanobacteria. HIV Med. 5(6):391-393. www.ncbi.nlm.nih.gov

Sommer, A. P., A. M. Pretorius, E. O. Kajander, and U. Oron. 2004. Biomineralization induced by stressed nanobacteria. Crystal Growth & Design. 4 (1): 45-46. Click here to view study.

Sommer, A. P., N. C. Wichramasinghe.  2005.  Functions and Possible Provenance of Primordial Proteins-Part II: Microorganism Aggregation in Clouds Triggered by Climate Change.  Journal of Proteome Research. 4: 180-184. Click here to view study.

Wang, X.J., Liu, W., Yang, Z.L., Wei, H., Wen, Y., Li, Y.G. 2004. The detection of nanobacteria infection in serum of healthy Chinese people. Zhonghua Liu Xing Bing Xue Za Zhi. 25(6): 494-4. Click here to view study.

Wilk, I., G. Martirosian, K. Z. Mikrobiologii, S. A. Medycznei, Khatowice. 2004. Nanobacteria microbiological characteristic. Postepy Hig Med Dosw (online), 2004; 58: 60-64. Click here to view study.

Aho K, Kajander EO. 2003. Detection of novel nanoorganisms .J Clin Microbiol. 41(7): 3460-3461. Click here to view study.

Barr S. C., R. A. Linke, D. Janssen, C. L. Guard, M. C. Smith, C. S. Daugherty, J. M. Scarlett. 2003. Detection of biofilms formation and nanobacteria under long-term cell culture conditions in serum samples of cattle, goats, cats and dogs. Am J Vet Res. 64(2):176-182. 

Miller-Hjelle, M. A., J. T. Hjelle, N. Ciftcioglu and E. O. Kajander. 2003. Nanobacteria: methods for growth and identification of this recently discovered calciferous agent. Rapid Analytical Microbiology. The chemistry and physics of microbial identification. Ed. . Olson. PDA, Bethesda, MD, USA. 297-312. Click here to view study.

Miller-Hjelle, M. A., S. L. Stobbs, I. R. Poxton, J. T. Hjelle. 2003. Nanobacteria antigen and antibody titres in USA controls compared to UK controls and kidney disease patients. 13th European Congress of Clinical Microbiology & Infectious Diseases. P1663. Click here to view study.

Sedivy, R., and W. B. Battistutti. 2003. Nanobacteria promote crystallization of psammoma bodies in ovarian cancer. APMIS III. 951-4. Click here to view study.

Sommer, A. P. 2003. Peripheral neuropathy and light preliminary report indicating prevelence of nanobacteria in HIV. Journal of Proteome Research.2: 665-666. Click here to view study.

Sommer, A. P., D. S. McKay, N. Ciftcioglu, U. Oron, A. R. Mester, and E. O. Kajander. 2003. Living nanovesicles-chemical and physical survival strategies of primordial biosystems. Perspectives, J. Proteome Res. 2:441-443. Click here to view study.

Sommer, A. P., U. Oron, A. M. Pretorius, D. S. McKay, N. Ciftcioglu, A. R. Mester, E. O. Kajander and H. T. Whelan. 2003. A preliminary investigation into light-modulated replication of nanobacteria and heart disease. J. Clin. Laser Med. Surg. 21 (4): 231-235. Click here to view study.

Ciftcioglu, N., M. A. Miller-Hjelle. J. T. Hjelle and E. O. Kajander. 2002. Inhibition of nanobacteria as measured by a modified microdilution method. Antimicrob Agents Chemother. 46: 2077-2086. Click here to view study.

Kajander, E. O., K. Aho and V. Segal. October, 2002. Apatite biofilm forming agent: nanobacteria as a model system for biomineralization and biological standard for noa, a preliminary study. Proceedings of the 2nd International Conference on Near-Field Optical analysis: Photodynamic Therapy & Photobiology Effects. Houston, Texas. Click here to view study.

Sommer A. P., H. I. Hassinen, E. O. Kajander. 2002. Light-induced replication of nanobacteria: a preliminary report. J Clin Laser Med Surg.20(5):241-244.www.ncbi.nlm.nih.gov

Sommer, A. P., U. Oron, E. O. Kajander and A. R. Mester. 2002. Stressed cells survive better with light. J. Proteome Res.1:475. Click here to view study.

Breitschwerdt, E. B., Sushama, S., Cannedy, A., Hancock, S. I., Bradley. J. M. 2001. Infection with Bartonella weissii and detection of nanobacterium antigens in a North Carolina beef herd Journal of Clinical Microbiology. 879-882. Click here to view study.

Vali, H., M. D. McKee, N. Ciftcioglu, S. K. Sears, F. L. Plows, E. Chelvet, P. Ghiasi, E. O. Kajander and R. N. Zare. 2001. Nanoforms: a new type of protein-associated mineralization. Geochim.Cosmochim. Acta. 65:63-74. Click here to view study.

Ciftcioglu, N. and E. O. Kajander. 2000. Nanobacterial growth factors for nanobacteria Proc. SPIE. 3755: 113-119. Click here to view study.

Kajander, E. O. and N. Ciftcioglu. 2000. Nanobacteria as extremophiles Proc. SPIE. 3755: 106-112. Click here to view study.

Vainshtein M. B., E. B. Kudriashova. 2000. About nanobacteria. Mikrobiologiia (Russian). 69(2):163-174. www.ncbi.nlm.nih.gov

Abbott, A. 1999. Battle lines drawn between nanobacteria researchers. 1999. Nature. 401 (6749):105. www.ncbi.nlm.nih.gov

Ciftcioglu, N. 1999. Microbial presence versus pathogenicity. Pleomorphic microbes in health and disease. Proceedings of the first annual symposium held June 18-19. Edited by: Gitte S. Jensen Ph.D. Holger N.I.S. Inc.; 49-53. Click here to view study.

Kajander, E. O., M. Bjorklund, N. Ciftcioglu. 1999. Nanobacteria and man. Enigmatic Microorganisms and Life in Extreme Environments. Eds.J. Seckbach, Kluwer (the Netherlands). 195-204. Click here to view study.

Kajander, E. O. 1999. Nanobacteria in health and disease. Pleomorphic microbes in health and disease. Proceedings of the first annual symposium held June 18-19, 1999. Edited by: Gitte S. Jensen Ph.D. Holger N.I.S. Inc. Hudson, Quebec; 43-48. Click here to view study.

Kajander, E. O., T. Heinonen, I. Kuronen, K. Luoto and N. Ciftcioglu. 1999. A new problem for sterile filtration; nanobacteria. In Proceedings, WorldPharm. 99, October 26-28, 1999, Philadelphia. Advanstar Communications, Cleveland, OH. Pp. 243-252. Click here to view study.

Kajander, E. O., T. Heinonen, I. Kuronen, K. Luoto, and N. Ciftcioglu. Nanobacteria, mycoplasma and bacterial l-forms; problems for sterile filtration. 30th R3. Nordic Contamination Control Symposium.Helsinki, Finland. Click here to view study.

Southam, G., R. Donald. 1999. A structural comparison of bacterial microfossils vs. nanobacteria and nanofossils. Earth-Science Reviews.48 (4): 251-264.

Wainwright, M. 1999. Nanobacteria and associated elementary bodies in human disease and cancer. Microbiology. 145: 2623-2624. Click here to view study.

Bjorklund, M., N. Ciftcioglu, E. O. Kajander. 1998. Extraordinary survival of nanobacteria under extreme conditions. Proc. SPIE. 3441: 123-129. Click here to view study.

Carson, D. A. 1998. An infectious origin of extraskeletal calcification. PNAS.95: 7846-7847. Click here to view study.

Ciftcioglu, N., E. O. Kajander. 1998. Interaction of nanobacteria with cultured mammalian cells. Pathophysiology. 4: 259-270. Click here to view study.

Ciftcioglu, N., M. Bjorklund, E. O. Kajander. 1998. Stone formation and calcification by nanobacteria in human body. Proc. SPIE.3441: 105-111. Click here to view study.

Ciftcioglu, N., V. Ciftcioglu, H. Vali, E. Turcott, E. O. Kajander. 1998. Sedimentary rocks in our mouth: dental pulp stones made by nanobacteria.Proc. SPIE. 3441: 130-135. Click here to view study.

Kajander, E. O., M. Bjorklund and N. Ciftcioglu. 1998. Suggestions from observations on nanobacteria isolated from blood. Size limits of very small microorganisms: proceedings of a workshop, steering group on astrobiology of the Ciftcioglu, N., M. Bjorklund, K. Kuorikoski, K. Click here to view study.

Bergstrom and EO. Kajander. 1999. Nanobacteria: An infectious cause for kidney stone formation. Kidney International. 56:1893-1898. www.ncbi.nlm.nih.gov studies board National Research Council; Washington, D.C. October 22-23.

Kajander, E. O., N. Ciftcioglu, M. Bjorklund. 1998. Mineralization by nanobacteria Proc. SPIE. 3441: 86-94. Click here to view study.

Kajander, E. O., N. Ciftcioglu. 1998. Nanobacteria: An alternative mechanism for pathogenic intra- and extracellular calcification and stone formation Proc. Natl. Acad. Sci. USA 95: 8274-8279. Click here to view study.

Akerman, K. K., J. T. Kuikka, N. Ciftcioglu, J. Parkkinen, K. A. Bergstrom, I. Kuronen, and E. O. Kajander. 1997. Radiolabeling and in vivo distribution of nanobacteria in rabbit. Proc. SPIE. 3111: 436-442. Click here to view study.

Ciftcioglu, N., A. Pelttari, E. O. Kajander. 1997. Extraordinary growth phases of nanobacteria isolated from mammalian blood. Proc. SPIE. 3111: 429-435. Click here to view study.

Cifcioglu, N., I. Kuronen, K. Akerman, E. Hiltunen, J. Laukkanen, E.O. Kajander. 1997. E. F. Brown, D. Burton, P. Doherty, J. Makalanos, E. Norrby. A new potential threat in antigen and antibody products: nanobacteria. Cold spring harbor laboratory. Vaccines 97. 99-103. Click here to view study.

Kajander, E. O., I. Kuronen; K. Akerman, A. Pelttari, N. Ciftcioglu. 1997. Nanobacteria from blood, the smallest culturable autonomously replicating agent on earth. Proc. SPIE. 3111: 420-428. Click here to view study.

Kajander, E. O., E. Tahvanainen, I. Kuronen, N. Ciftcioglu. 1994. Comparison of staphylococci and novel bacteria-like particles from blood. Zbl. Bakt. (Suppl.) 26: 147-149. Click here to view study.

Akerman, K. K., I. Kuronen, and E. O. Kajander. 1993. Scanning electron microscopy of nanobacteria-novel biofilm producing organisms in blood. Scanning. 15 (Suppl.) 3:90-91. Click here to view study.